Subsequently, PAMPs can result in vascular leak and hypovolemic shock, immune and inflammatory responses and metabolic changes. Following severe burn injury, damaged tissues lead to the release of endogenous DAMPs (such as double-stranded RNA and mitochondrial DNA) and exogenous PAMPs (such as lipopolysaccharides and peptidoglycans). Published by Oxford University Press.Ī series of pathogenic events responsible for sepsis post burn injury. Moreover, the clinical and promising biomarkers of burn sepsis will also be summarized.īiomaker Burn Hypermetabolism Immune dysregulation Infection Inflammation Multiple organ dysfunction syndrome Sepsis Septic shock Trauma. In this review, we focus on the pathogenesis of burn wound infection and the post-burn events leading to sepsis. Therefore, clear diagnostic criteria and predictive biomarkers are especially important in the prevention and treatment of sepsis and septic shock.

Indeed, burn injuries are accompanied by a series of events that lead to sepsis and multiple organ dysfunction syndrome, such as a hypovolaemic state, immune and inflammatory responses and metabolic changes.

One of the most common complications of burn is sepsis, which is defined as 'severe organ dysfunction attributed to host's disordered response to infection' and is the primary cause of death in burn patients. Although the survival rate after devastating burn injuries has continued to increase in previous decades due to medical advances in burn wound care, nutritional and fluid resuscitation and improved infection control practices, there are still large numbers of patients at a high risk of death. Burn is an under-appreciated trauma that is associated with unacceptably high morbidity and mortality.

Sepsis burn